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Case Series
Erectile dysfunction: Three rare cases of Qsymia side effect
1 Case Western Reserve University School of Medicine, Cleveland, OH, USA
2 Louis Stokes Veterans Affairs Medical Center, Cleveland, OH, USA
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Haitong Yu
BS, 9501 Euclid Ave, Cleveland, OH 44106,
USA
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Article ID: 100082Z09HY2025
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Yu H, Sood P. Erectile dysfunction: Three rare cases of Qsymia side effect. J Case Rep Images Med 2025;11(2):9–12.ABSTRACT
Introduction: Sold under the brand name of Qsymia, the combination of phentermine and topiramate is a common medication used as an adjunct therapy for weight loss. Despite previous animal studies showing adverse effect to male rate infertility, sexual dysfunction including erectile dysfunction (ED) was not reported as an adverse effect for patient with obesity taking Qsymia.
Case Report: We presented three cases of patients with obesity who reported ED as an adverse effect of Qsymia with two cases demonstrating reversibility with either discontinuation of the medication or supplementation with Sildenafil. All the patients have comorbidities for ED and two patients have predisposition to ED. We discussed the potential mechanisms of action for the different components of Qsymia causing ED in the three cases by reviewing previous literatures.
Conclusion: Given the reversibility of ED and sufficient therapeutic effects, Qsymia should remain as the adjunct therapy for obesity along with diet modification and physical activities.
Keywords: Adverse effect, Erectile dysfunction, Obesity, Qsymia
SUPPORTING INFORMATION
Acknowledgments
We would like to thank our patients for allowing us to write this case report.
Author ContributionsHaitong Yu - Analysis of data, Interpretation of data, Drafting the article, Revising it critically for important intellectual content, Final approval of the version to be published
Pratima Sood - Substantial contributions to conception and design, Acquisition of data, Revising it critically for important intellectual content, Final approval of the version to be published
Guaranter of SubmissionThe corresponding author is the guarantor of submission.
Source of SupportNone
Consent StatementWritten informed consent was obtained from the patient for publication of this article.
Data AvailabilityAll relevant data are within the paper and its Supporting Information files.
Conflict of InterestAuthors declare no conflict of interest.
Copyright© 2025 Haitong Yu et al. This article is distributed under the terms of Creative Commons Attribution License which permits unrestricted use, distribution and reproduction in any medium provided the original author(s) and original publisher are properly credited. Please see the copyright policy on the journal website for more information.
